General GI Conditions
Overview
Dr. Dougan’s clinical and research interests expand to many GI conditions, including Celiac disease, eosinophilic diseases, collagenous gastritis, and more.
Ongoing projects
A Study of Dupilumab in Adults with Eosinophilic Gastritis with or without Eosinophilic Duodenitis (ENGAGE)
Sponsor: Regeneron Pharmaceuticals
A randomized, double-blind, placebo-controlled clinical trial studying the safety and efficacy of dupliumab in patients with eosinophilic gastritis (EoG) who may or may not also have eosinophilic duodenitis (EoD).
Celiac Disease in Adults Repository (CEDAR) Study
A biorepository study that collects biological samples and related health information to be used for future research involving Celiac disease.
MGH Adult Eosinophilic Esophagitis (EoE) Registry
A biorepository study that collects biological samples and related health information to be used for future research involving EoE.
Comparison of Antibody Concentration in Saliva vs. Serum in Adults Initiating New Monoclonal Antibody Treatment
A study using the VeraPrep Antibody Detection Platform developed by Veravas, Inc. to study the effectiveness of measuring therapeutic monoclonal antibody levels in saliva samples compared to blood samples.
Collection of Biologic Samples and Clinical Data in Patients with Gastrointestinal Malignancies
A biorepository study led by Dana-Farber Cancer Institute that evaluates how genetic and biologic factors may contribute to the development of gastrointestinal tumors. At MGH, our goal is to collect samples and data from patients with different non-cancerous GI conditions (like Celiac disease, EoE, and others) to provide a comparison to patients with GI malignancies.
Upcoming projects
Vedolizumab for the Treatment of Collagenous Gastritis
A single-arm clinical trial studying the use of vedolizumab (Entyvio) to treat patients with collagenous gastritis.
Immunological Biomarkers in Celiac Disease after Gluten Challenge
An interventional study that collects biological samples from patients with Celiac disease after exposure to gluten. The goal of this study is to help create new tests that can accurately measure the immune system’s response to gluten, and to use those tests in future clinical studies.